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Biotechnology Information microarray dataset gse138614
TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( <t>GSE138614</t> ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm
Microarray Dataset Gse138614, supplied by Biotechnology Information, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+dataset/dataset+gse138614+microarray/pmc13123086-29-1-18
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1) Product Images from "TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination"

Article Title: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination

Journal: Journal of Neuroinflammation

doi: 10.1186/s12974-026-03769-4

TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm
Figure Legend Snippet: TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm

Techniques Used: Expressing, Control, Gene Expression, Microarray, Quantitative RT-PCR, Western Blot, Immunofluorescence, Marker

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Microarray:

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Article Snippet: .. The original microarray dataset are available at the National Center of Biotechnology Information Gene Expression Omnibus database ( https://www.ncbi.nlm.nih.gov/geo/ ) with the accession numbers GSE103611 and GSE102349. ..

Article Title: Bioinformatics analysis identifies potential biomarkers involved in the metastasis of locoregionally advanced nasopharyngeal carcinoma
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Article Title: Identification of differentially expressed hub genes in Alzheimer’s disease using microarray dataset
Article Snippet: An important factor that leads to the progression of Alzheimer’s disease is the amyloid-β peptide.. Improper degradation of such molecules accompanied by reduced synaptic signaling contributes to the disease.. Thus, a critical understanding of proteins interacting in peptide degradation, synaptic transmission and cognition is important to understand the disease progression.

Article Title: Computational and Bioinformatics Approaches for Identifying Comorbidities of COVID-19 Using Transcriptomic Data
Article Snippet: .. For our investigation, we collected the dataset from National Center for Biotechnology Information (NCBI) (https://www.ncbi.nlm.nih.gov/) with accession number GSE166552 which is a microarray dataset prepared from blood samples of COVID-19 patients and healthy people. ..

Article Title: Hypoxia-inducible factor 1α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cells
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Gene Expression:

Article Title: Bioinformatics analysis identifies potential biomarkers involved in the metastasis of locoregionally advanced nasopharyngeal carcinoma
Article Snippet: .. The original microarray dataset are available at the National Center of Biotechnology Information Gene Expression Omnibus database ( https://www.ncbi.nlm.nih.gov/geo/ ) with the accession numbers GSE103611 and GSE102349. ..

Article Title: Bioinformatics analysis identifies potential biomarkers involved in the metastasis of locoregionally advanced nasopharyngeal carcinoma
Article Snippet: .. The original microarray dataset are available at the National Center of Biotechnology Information Gene Expression Omnibus database (https://www.ncbi. nlm.nih.gov/geo/) with the accession numbers GSE103611 and GSE102349. ..

Article Title: Identification of differentially expressed hub genes in Alzheimer’s disease using microarray dataset
Article Snippet: An important factor that leads to the progression of Alzheimer’s disease is the amyloid-β peptide.. Improper degradation of such molecules accompanied by reduced synaptic signaling contributes to the disease.. Thus, a critical understanding of proteins interacting in peptide degradation, synaptic transmission and cognition is important to understand the disease progression.

Article Title: Hypoxia-inducible factor 1α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cells
Article Snippet: .. The gene expression profiling with microarray dataset, accession number GSE77573 and GSE33224, was procured from the National Center of Biotechnology Information (NCBI) GEO database ( http://www.ncbi.nlm.nih.gov/geo/ ). ..

Article Title: Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α
Article Snippet: .. A microarray dataset obtained from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO) (accession number GSE58772) was used to define the signature genes for lung MPC. ..

Article Title: Dimethyl Fumarate Induces Apoptosis via Inhibition of NF-κB and Enhances the Effect of Paclitaxel and Adriamycin in Human TNBC Cells
Article Snippet: .. The gene expression profiles in the microarray dataset (accession number GSE45827) were procured from the National Center of Biotechnology Information Gene Expression Omnibus database ( http://www.ncbi.nlm.nih.gov/geo/ (accessed on 9 June 2022)). ..

Expressing:

Article Title: MicroRNA‑606 inhibits the growth and metastasis of triple‑negative breast cancer by targeting Stanniocalcin 1
Article Snippet: G-Fectin and Lipofectamine ® 3000 transfection reagents were purchased from Genolution, Inc. and Invitrogen; Thermo Fisher Scientific, Inc., respectively. .. To investigate the expression of miRNAs in patients with breast cancer, a microarray dataset (GSE118782) was obtained from the publicly available GEO database (National Center for Biotechnology Information; http://www.ncbi.nlm.nih.gov/geo ). .. The GSE118782 dataset includes RNA extracted from the plasma of 30 patients with breast cancer and 10 healthy control women; the levels of small noncoding RNA were quantitated using Affymetrix microarrays ( ).



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Image Search Results


TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm

Journal: Journal of Neuroinflammation

Article Title: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination

doi: 10.1186/s12974-026-03769-4

Figure Lengend Snippet: TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm

Article Snippet: The microarray dataset GSE138614 was retrieved from the Gene Expression Omnibus (GEO) repository of the National Center for Biotechnology Information ( https://www.ncbi.nlm.nih.gov/geo/ ).

Techniques: Expressing, Control, Gene Expression, Microarray, Quantitative RT-PCR, Western Blot, Immunofluorescence, Marker

SIRT3 is downregulated in RCC. ( A ) Based on the GEO GSE53757 dataset, SIRT3 mRNA levels in RCC tissues were compared with those in normal tissues. ( B ) SIRT3 protein levels in RCC tissues were analyzed in comparison to adjacent normal tissues using CPTAC data. ( C ) SIRT3 protein levels in RCC tissues and normal tissues were detected using immunohistochemistry (IHC). A scatter plot was generated to display the expression of SIRT3 in adjacent normal tissues versus RCC tissues. ( D, E ) Enrichment plots were produced to illustrate the gene expression signatures for proliferation (CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN) and migration (GOBP_ENDOTHELIAL_CELL_MIGRATION). *** P < 0.001.

Journal: Scientific Reports

Article Title: SIRT3 suppresses renal cancer progression by regulating IDH2 acetylation

doi: 10.1038/s41598-026-37783-6

Figure Lengend Snippet: SIRT3 is downregulated in RCC. ( A ) Based on the GEO GSE53757 dataset, SIRT3 mRNA levels in RCC tissues were compared with those in normal tissues. ( B ) SIRT3 protein levels in RCC tissues were analyzed in comparison to adjacent normal tissues using CPTAC data. ( C ) SIRT3 protein levels in RCC tissues and normal tissues were detected using immunohistochemistry (IHC). A scatter plot was generated to display the expression of SIRT3 in adjacent normal tissues versus RCC tissues. ( D, E ) Enrichment plots were produced to illustrate the gene expression signatures for proliferation (CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN) and migration (GOBP_ENDOTHELIAL_CELL_MIGRATION). *** P < 0.001.

Article Snippet: The GSE53757 microarray dataset was obtained through the National Center for Biotechnology Information Gene Expression Omnibus database (NCBI GEO, https://www.ncbi.nlm.nih.gov/gds/?term=GSE53757 ).

Techniques: Comparison, Immunohistochemistry, Generated, Expressing, Produced, Gene Expression, Migration